On one of our systems we've been using OTRS 5.0.11 for some time

Instead we have
1. Proxy Error
The proxy serv. received an invalid response from an upstream server.
The proxy server could not handle the request
Reason: Error reading from remote server
2. High CPU usage (100%) during loading of those tickets and after - reboot helps.
command /opt/otrs/bin/c by www-data user
I don't know what is the cause of this behaviour. Those ticktets may be a bit complex in their stucture (20-40 messages, attachements, long conversations, etc.)
Can anyone suggest something to make the system work as it should ?